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Concerted research efforts over the last three decades have resulted in improved survival and outcomes for patients diagnosed with nasopharyngeal carcinoma (NPC).The evolution of radiotherapy techniques has facilitated improved dose delivery to target volumes while reducing dose to click here the surrounding normal tissue, improving both disease co
Metabolic cycles are a fundamental element of cellular and organismal function.Among the most critical in higher organisms is the click here Cori Cycle, the systemic cycling between lactate and glucose.Here, skeletal muscle-specific Mitochondrial Pyruvate copyright (MPC) deletion in mice diverted pyruvate into circulating lactate.This switch disinh
The evolution of stem cell-based heart models from cells and tissues to organoids and assembloids and recently synthetic embryology gastruloids, is poised to revolutionize our understanding of cardiac development, congenital to adult diseases, and patient customized therapies.Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) ha